Tracked shipping to South Africa with premium packaging for just R199 

Ship to
South Africa
0

My Account

  • argentina
  • chile
  • colombia
  • españa
  • méxico
  • perú
  • estados unidos
  • internacional

menu

Select your country

Americas

Europe

Rest of the world

portada Alzheimer Disease: Therapeutic Strategies
Type
Physical Book
Publisher
Author
Language
English
Pages
510
Format
Paperback
Dimensions
23.4x15.6x2.7 cm
Weight
0.73 kg.
ISBN13
9781461581512
Categories

Alzheimer Disease: Therapeutic Strategies

Smith, D. L. ; Giacobini, Ezio ; Barton, J. M. (Author) · Birkhauser · Paperback

Alzheimer Disease: Therapeutic Strategies - Smith, D. L. ; Giacobini, Ezio ; Barton, J. M.

Cheaper New Book Imported to South Africa
Delivery: 05 Oct - 13 Oct Shipping: 16 to 17 business days.
R 1,018
Faster New Book Imported to South Africa
Delivery: 21 Sep - 29 Sep Shipping: 6 to 7 business days.
R 1,236
R 1,018

Choose the list to add your product or create one New List

Go to My Wishlists
Calculate shipping cost

Synopsis "Alzheimer Disease: Therapeutic Strategies"

Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.

Customers reviews

More customer reviews
  • 0% (0)
  • 0% (0)
  • 0% (0)
  • 0% (0)
  • 0% (0)

Frequently Asked Questions about the Book

Is the book original?

All books in our catalog are Original.

In what language is the book written?

The book is written in English.

What is the format of this book?

The binding of this edition is Paperback.

Questions and Answers about the Book

Do you have a question about the book? Login to be able to add your own question.

Opinions about Bookdelivery

More customer reviews