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portada Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation
Type
Physical Book
Publisher
Author
Language
English
Pages
400
Format
Paperback
ISBN13
9780443366369

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation

Prabhakar, Pranav Kumar; Prakash, Ajit; Khan, Mohammad Ashhar Iqbal (Author) · Academic Press · Paperback

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation - Prabhakar, Pranav Kumar; Prakash, Ajit; Khan, Mohammad Ashhar Iqbal

New Book Imported to South Africa
Delivery: 21 Sep - 21 Oct Shipping: 55 to 61 business days.
R 4,133
R 4,133

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Synopsis "Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation"

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book provides a comprehensive overview of pathological protein aggregation, exploring its mechanisms in the context of specific illnesses, including Alzheimer's disease, Parkinson's disease, Huntington's disease, prion diseases, ALS and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. It also features structural insights into protein aggregates from amyloid fibrils to inclusion bodies, and offers therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions. Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. "Protein Misfolding and Human Diseases" serves as an invaluable reference on the intricacies of protein misfolding and its clinical implications. It takes an interdisciplinary approach to the topic, integrating insights across biophysics, cell biology, structural biology, neuroscience and medicine. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders. Pharmaceutical and biotechnology professionals involved in drug discovery and development targeting protein misfolding pathways will also benefit greatly.

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