Name: Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents
Price: 1204.00 ZAR
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Author: Kawsar, S. M. Abe ; Alam, Asraful
ISBN: 9786202531658

portada Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents

Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents

Type

Physical Book

Author

Asraful Alam

S. M. Abe Kawsar

Publisher

LAP Lambert Academic Publishing

Language

English

Pages

148

Format

Paperback

Dimensions

22.9 x 15.2 x 0.9 cm

Weight

0.23 kg.

ISBN13

9786202531658

Synopsis "Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents"

Nucleosides and their analogues are of immense importance and they are an established class of clinically useful medicinal agents possessing antifungal, antibacterial, antiviral and anticancer activity. This has led to our interest in the search for a synthesis of new nucleoside molecule i.e., thymidine analogues that may be screened for broad-spectrum biological activity. Thymidine analogues, containing heterocyclic systems, are known to possess various therapeutic activities for the treatment of human diseases. Thymidine analogues such as telbibudine (thymidine α-L-nucleoside analogue), AZT (3׳-azido-2׳,3׳-dideoxythymidine), stavudine, zalcitabine are being used as antiviral, and HIV, drugs. In our present investigation, four new series of nucleoside derivatives were synthesized from thymidine (1) via only two-step reactions by direct acylation method and furnished the 5 -O-acyl thymidine derivatives in good yields. To obtain newer products for antimicrobial evaluation studies, the 5 -O-thymidine derivatives were further transformed into two series of 2 ,3 -di-O-acyl derivatives (scheme 1-4) containing a wide variety of functionalities in a single molecular framework.

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Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents - Kawsar, S. M. Abe ; Alam, Asraful

Synopsis "Synthesis of Thymidine Analogues as Antimicrobial & Anticancer Agents"

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