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portada Anca-Associated Vasculitides: Immunological and Clinical Aspects
Type
Physical Book
Publisher
Author
Language
English
Pages
552
Format
Paperback
Dimensions
25.4 x 17.8 x 3.0 cm
Weight
0.99 kg.
ISBN13
9781475791846
Categories

Anca-Associated Vasculitides: Immunological and Clinical Aspects

Gross, Wolfgang L. (Author) · Springer · Paperback

Anca-Associated Vasculitides: Immunological and Clinical Aspects - Gross, Wolfgang L.

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Synopsis "Anca-Associated Vasculitides: Immunological and Clinical Aspects"

WEGENER'S GRANULOMATOSIS & ANCA-ASSOCIATED DISEASES: THE STORY CONTINUES The disease now designated as Wegener's granulomatosis (WG) was first described in 1931 by Heinz Klinger, who considered it to be a special form of polyarteritis nodosa. Klinger's friend, Friedrich Wegener, expanded on the first observations and interpreted the pathological and clinical fmdings to represent a distinct disease entity (Wegener, 1939). He described this entity as a "peculiar rhinogenous granulomatosis with a unique participation of the arterial system and the kidneys". Later, Godman and Churg (1954) established the classical diagnostic criteria (the "WG triad"): granuloma, vasculitis, and glomerulonephritis. In 1958 Walton pointed out the poor prognosis of WG based on a small number of published cases (mean survival time: 5 months). In 1966 Carrington and Liebow reported "limited forms" of WG with a defmitely more favorable prognosis. Since then positive results have been reported with cyclophosphamide therapy. In addition, a retrospective study of combined low-dose cyclophosphamide and prednisolone in 85 WG patients over a period of 21 years found a similarly encouraging outcome. The-latter experience led to the current "standard" treatment protocol (FAUCI et al., 1973 and 1983). More recently, strong evidence has emerged that some of the morbidity and mortality ofWG - and other types of systemic vasculitis - may be a consequence of this treatment (Hoffman et al., 1992).

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