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portada Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals
Type
Physical Book
Publisher
Author
Year
2017
Pages
180
Format
Paperback
Dimensions
27.9x21.6x2.5 cm
ISBN13
9780309458627

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals

Board On Environmental Studies And Toxicology;Engineering, And Medicine National Academies Of Sciences;Division On Earth And Life Studies;Committee On Endocrine-Related Low-Dose Toxicity (Author) · National Academies Press · Paperback

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals - Board on Environmental Studies and Toxicology;Engineering, and Medicine National Academies of Sciences;Division on Earth and Life Studies;Committee on Endocrine-Related Low-Dose Toxicity

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Synopsis "Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals"

To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects. Table of ContentsFront MatterSummary1 Introduction2 Strategy for Evaluating Low-Dose Effects3 Phthalates and Male Reproductive-Tract Development4 Effect of Polybrominated Diphenyl Ethers on Neurodevelopment5 Lessons Learned and Reflections on the Statement of TaskAppendix A: Biosketches of the Committee on Endocrine-Related Low-Dose ToxicityAppendix B: Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose ToxicityAppendix C: Supporting Materials for the Phthalate (Animal) Systematic ReviewAppendix D: Supporting Materials for the Phthalate (Human) Systematic ReviewAppendix E: Supporting Materials for the PBDE (Animal) Systematic ReviewAppendix F: Supporting Materials for the PBDE (Human) Systematic Review

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