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portada Design, Synthesis and Anti-Hiv Activity of Curcumin Analogues
Type
Physical Book
Publisher
Author
Language
English
Pages
72
Format
Paperback
ISBN13
9783659750014

Design, Synthesis and Anti-Hiv Activity of Curcumin Analogues

Ahsan Mohamed Jawed; Sharma Sachin Kumar (Author) · Lap Lambert Academic Publishing · Paperback

Design, Synthesis and Anti-Hiv Activity of Curcumin Analogues - Ahsan Mohamed Jawed; Sharma Sachin Kumar

New Book Imported to South Africa
Delivery: 03 Sep - 11 Sep Shipping: 13 to 14 business days.
R 817
R 817

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Synopsis "Design, Synthesis and Anti-Hiv Activity of Curcumin Analogues"

A series of 11 curcumin analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for anti-HIV screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (3a-k) were evaluated for anti-HIV activity as per the standard protocol. Maximum drug-likeness model score (1.1.0) was found for 3,5-bis(4-hydroxy-3-methylstyryl)-N-(4-chlorophenyl)-1H-pyrazole-1-carboxamide (3b). The compound 3b was found to have anti-HIV activity with IC50 >3.71 M and CC50 3.71 M, however the activity was found to be less than the standard drug zidovudine.

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