Name: Drug Sensitivity Assay on Biofilm Development in Mycobacteria
SKU: 57594598
Price: 796.00 ZAR
Availability: InStock
Author: Bhardwaj, Nikunaj ; Sharma, V. K. ; Goyal, Jaideep
ISBN: 9786202554978

portada Drug Sensitivity Assay on Biofilm Development in Mycobacteria

Drug Sensitivity Assay on Biofilm Development in Mycobacteria

Type

Physical Book

Author

V. K. Sharma

Nikunaj Bhardwaj

Jaideep Goyal

Publisher

LAP Lambert Academic Publishing

Language

English

Pages

Format

Paperback

Dimensions

22.9x15.2x0.5 cm

Weight

0.12 kg.

ISBN13

9786202554978

Synopsis "Drug Sensitivity Assay on Biofilm Development in Mycobacteria"

The bacteria enclosed within the biofilm are extremely resistant to antibiotic treatments; such resistancecan be explained by hypotheses, not necessarily limited to the following ones. First, the EPS secreted bybiofilm bacteria, acts as a physical/chemical barrier, thus preventing penetration by antibodies or manyantibiotics. The EPS is negatively charged and functions as an ion-exchange resin which is capable ofbinding a large number of the antibiotic molecules that are attempting to reach the embedded biofilmcells. Second, embedded biofilm bacteria are generally not actively engaged in cell division, are smallerin size and less permeable to antibiotics. We demonstrate here for the first time that biofilm cultures of aMycobacterium are capable of growing at higher drug concentrations (i.e. have higher MICs) thansuspension cultures. The MIC of selected drugs concentration that inhibited exponentially growingbiofilm was found to be higher than the MIC for planktonic culture. The biofilm literature offers essentiallythree possible explanations for biofilm-associated drug resistance: (i) Slower biofilm growth, (ii)Decreased drug penetration into the bioflm due to architecture and/or e

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Drug Sensitivity Assay on Biofilm Development in Mycobacteria - Bhardwaj, Nikunaj ; Sharma, V. K. ; Goyal, Jaideep

Synopsis "Drug Sensitivity Assay on Biofilm Development in Mycobacteria"

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