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portada IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITION OF FLAVONOIDS
Type
Physical Book
Publisher
Author
Year
2026
Language
English
Pages
96
Format
Paperback
Dimensions
22.90 x 15.20 x 0.50 cm
ISBN13
9786209863264

IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITION OF FLAVONOIDS

M. Vijayabaskaran;E. Kape Meyar;A. Madeswaran (Author) · LAP Lambert Academic Publishing · Paperback

IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITION OF FLAVONOIDS - M. VIJAYABASKARAN;E. KAPE MEYAR;A. MADESWARAN

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Synopsis "IN SILICO AND IN VITRO ALDOSE REDUCTASE INHIBITION OF FLAVONOIDS"

Cataracts are one of the primary causes of visual impairment in diabetics. Patients with diabetes mellitus are said to be five times more likely to acquire cataracts, particularly if they begin the condition early. Flavonoids are bioactive secondary metabolites of plants that belong to a large family of low molecular weight compounds and have a polyphenolic structure. This comprehensive book explores the therapeutic potential of novel flavonoid derivatives in combating diabetic cataractogenesis. Utilizing a multi-disciplinary approach, the research integrates in silico molecular docking to identify high-affinity aldose reductase inhibitors (ARIs) with traditional chemical synthesis and characterization techniques. The core of the investigation lies in a rigorous in vitro evaluation using isolated goat lenses, demonstrating how these specialized compounds retard lens opacification and mitigate oxidative stress. This book provides a critical scaffold for the development of non-surgical, plant-derived pharmacological interventions for vision preservation.

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