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portada Prostate Proto-Oncogene Molecular Action
Type
Physical Book
Author
Publisher
Language
English
Pages
156
Format
Paperback
Dimensions
22.9x15.2x0.9 cm
Weight
0.24 kg.
ISBN13
9786200460738
Categories

Prostate Proto-Oncogene Molecular Action

El Hassane Sidibé (Author) · LAP Lambert Academic Publishing · Paperback

Prostate Proto-Oncogene Molecular Action - Sidibé, El Hassane

New Book Imported to South Africa
Delivery: 16 Oct - 26 Oct Shipping: 13 to 14 business days.
R 1,200
R 1,200

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Synopsis "Prostate Proto-Oncogene Molecular Action"

MEK inhibition alone was less effective in inducing cytotoxicity than taxanes indicating that a down-regulation of activated ERK1/2 may be necessary but is not sufficient for taxane-induced antitumoral effects. In line with this notion, we show in a xenograft mouse model that prostate cancer cells that are resistant to docetaxel overexpress activated ERK1/2. Taken together, our findings underscore that the modulation of ERK1/2 activation, in concert with other mechanisms, plays an important role in taxane-induced antineoplastic effects on prostate cancer cells.These results suggest at least partially nonoverlapping effects of docetaxel and androgen deprivation therapy and hence help to understand recent clinical findings. A further elucidation of the mode of action of docetaxel would have important implications to optimize current treatment strategies and biomarker development for men with metastatic prostate cancer.

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