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portada Ras: Past, Present, and Future (Volume 153) (Advances in Cancer Research, Volume 153)
Type
Physical Book
Publisher
Author
Language
English
Pages
356
Format
Hardcover
ISBN13
9780128244852
Edition No.
1

Ras: Past, Present, and Future (Volume 153) (Advances in Cancer Research, Volume 153)

O'bryan John P.,Piazza Gary (Author) · Academic Press · Hardcover

Ras: Past, Present, and Future (Volume 153) (Advances in Cancer Research, Volume 153) - O'bryan John P.,Piazza Gary

New Book Imported to South Africa
Delivery: 20 Oct - 28 Oct Shipping: 6 to 7 business days.
R 3,537
R 3,537

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Synopsis "Ras: Past, Present, and Future (Volume 153) (Advances in Cancer Research, Volume 153)"

Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

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The binding of this edition is Hardcover.

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