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portada regulation of aldosterone biosynthesis: physiological and clinical aspects
Type
Physical Book
Author
Publisher
Year
2011
Language
English
Pages
364
Format
Paperback
Dimensions
24.4x17x2 cm
Weight
0.61 kg.
ISBN
3642831222
ISBN13
9783642831225
Edition No.
0002
Categories

regulation of aldosterone biosynthesis: physiological and clinical aspects

Jürg Müller (Author) · Springer · Paperback

regulation of aldosterone biosynthesis: physiological and clinical aspects - Müller, Jürg

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Synopsis "regulation of aldosterone biosynthesis: physiological and clinical aspects"

Sixteen years is a long time, not only in human life but also in the rapid history of contemporary endocrinology. Since the publication of the first edition of this monograph, numerous new lines of research and discoveries have greatly contrib- uted to our knowledge of the physiological and pathological regulation of aldos- terone biosynthesis in man and animals. The first reports about a sensitive ra- dioimmunoassay for plasma aldosterone and about a preparation of dispersed zona glomerulosa cells were published in 1970 (Mayes et al. 1970; Haning et al. 1970). These two developments alone turned out to have a tremendous impact on research in aldosterone physiology (for reviews see Coghlan et al. 1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had not yet been discovered. Angiotensin antagonists and con- verting-enzyme inhibitors were not yet available. The clinical syndrome of hypo- reninemic hypo aldosteronism was unknown. The possible roles of prostaglandins and dopamine in the control of aldosterone pwduction had not been considered. Cyclic AMP was then the only substance with a clearly established second-mes- senger function.

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