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portada Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy
Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and TherapyTransforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and TherapyTransforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy
Type
Physical Book
Publisher
Author
Language
English
Pages
786
Format
Hardcover
Dimensions
25.2x18.6x3.4 cm
Weight
1.81 kg.
ISBN
1588297152
ISBN13
9781588297150
Categories

Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy

Jakowlew, Sonia B. ; Heldin, C. -H (Author) · Humana · Hardcover

Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy - Jakowlew, Sonia B. ; Heldin, C. -H

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Synopsis "Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy"

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.

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