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portada tumor aneuploidy
Type
Physical Book
Illustrated by
Other
Publisher
Author
Year
1985
Language
English
Pages
141
Format
Paperback
Dimensions
24.4 x 17.0 x 0.8 cm
Weight
0.25 kg.
ISBN
3540153764
ISBN13
9783540153764
Categories

tumor aneuploidy

Thomas Büchner (Illustrated by) · M. Andreeff (Other) · B. Barlogie (Other) · Springer · Paperback

tumor aneuploidy - Büchner, Thomas ; Andreeff, M. ; Barlogie, B.

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Synopsis "tumor aneuploidy"

Chromosome abnormalities of cancer cells have been recognized for a long time, and have generally proven to be a highly specific marker ofmalignancy. The contri- butions collected in this book, "Tumor Aneuploidy", cover several major aspects of present knowledge conceming the occurrence and clinical significance of chromo- some abnormalities as delineated by karyotype analyses or measurements of the cellular DNA content. Certain non-random clonal chromosome losses, deletions and translocations ap- pear to represent primary genetic lesions of malignancies and reflect their clonal origin. Secondary intraneoplastic genetic evolution is suggested by major clonal ab- normalities of chromosome number and cellular DNA content. Both types of ge- netic changes have been reaching great relevance in cancer medicine, today. Although the Philadelphia chromosome was first discovered in chronic myelo- cytic leukemia (CML), by Nowell and Hungerford in 1960, new banding techniques developed in the 1970's were needed to identity this abnormality as a translocation between chromosomes 9 and 22 (t(9; 22)). Soon thereafter, further non-random translocations were detected and attributed to special diseases like t(8; 21) and t(15; 17) to acute myeloid leukemias (AML) and t(9; 22), t(4; 11), t(8; 14) to acute lymphoblastic leukemia (ALL).

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