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portada capillary electrophoresis of carbohydrates
Type
Physical Book
Illustrated by
Publisher
Author
Year
2010
Language
English
Pages
318
Format
Paperback
Dimensions
22.9x15.2x1.9 cm
Weight
0.49 kg.
ISBN
1617372064
ISBN13
9781617372063
Categories

capillary electrophoresis of carbohydrates

Pierre Thibault (Illustrated by) · Susumu Honda (Illustrated by) · Humana · Paperback

capillary electrophoresis of carbohydrates - Thibault, Pierre ; Honda, Susumu

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Synopsis "capillary electrophoresis of carbohydrates"

Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic acids and proteins are copied from a template in a repeated series of identical steps using the same enzymes, complex carbohydrates are formed by the sequential actions of cellular glycosyltransferases that specifically recognize unique s- strates. The molecular biology of these transferases and other carbohydra- modifying enzymes is providing important insights on oligosaccharide recognition events. While it is acknowledged that the definition of the protein complement of cells and tissues (the so-called proteome) remains an enormous task in this postgenomic era, the characterization of all glycans produced by individual organisms (referred to as the glycome) presents an equally imp- tant challenge. This task is further complicated by the fact that oligosacc- rides cannot presently be cloned. These complex carbohydrates exist in a staggering diversity of structures, linkages, and branching, thus providing an exquisite molecular repertoire for cellular interactions.

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